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Image Search Results
Journal: Pharmaceutics
Article Title: New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs
doi: 10.3390/pharmaceutics16050649
Figure Lengend Snippet: GI 50 values of tested compounds for KCL22 cells containing Bcr-Abl WT or mutated kinase domain in T315I (B8), E255K (F4), or Y253H (B10).
Article Snippet:
Techniques:
Journal: ChemMedChem
Article Title: Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase.
doi: 10.1002/cmdc.201700829
Figure Lengend Snippet: Calculated LogP and anti-proliferation activities of alkynyl analogs
Article Snippet: Evaluation of compounds activity against ABL1 and ABL1(T315I) inside CML cell lines KCL22 and
Techniques:
Journal: ChemMedChem
Article Title: Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase.
doi: 10.1002/cmdc.201700829
Figure Lengend Snippet: Inhibition of cellular ABL1 activity by imatinib, ponatinib and HSN compounds
Article Snippet: Evaluation of compounds activity against ABL1 and ABL1(T315I) inside CML cell lines KCL22 and
Techniques: Inhibition, Activity Assay